Potential Antiparasitic Effects of Ginger Tablets in Experimental Toxoplasmosis and Its Impact on Ensuing Brain Lesions

Mostafa, Reham R.; Atta, Shimaa A.; Fahmy, Zeinab H.; Selim, Eman A.H.; Aboushousha, Tarek; Attia, Samar S.; Abd-Alghany, Asmaa R.

doi:10.21608/eajbse.2025.431497

Potential Antiparasitic Effects of Ginger Tablets in Experimental Toxoplasmosis and Its Impact on Ensuing Brain Lesions

Document Type : Original Article

Authors

¹ Department of Medical Parasitology Faculty of Medicine, Cairo Universities, Cairo, Egypt.

² Department of Immunology, Theodor Bilharz Research Institute, Cairo, Egypt.

³ Department of Parasitology, Theodor Bilharz Research Institute, Cairo, Egypt.

⁴ Department of Pathology, Theodor Bilharz Research Institute, Cairo, Egypt.

10.21608/eajbse.2025.431497

Abstract

The intracellular protozoan parasite, Toxoplasma gondii (T. gondii) can result in serious manifestations in humans, especially pregnant women and immunocompromised persons. Standard drugs for treatment toxoplasmosis have serious side effects. Safe therapeutics are still needed. Our work aimed to ascertain the effectiveness of ginger tablets in treating chronic toxoplasmosis alone and in combination with spiramycin in mice model. Our experiment was conducted on 48 mice divided into 4 equal groups, Group (I) Infected non-treated control, Group (II) Infected treated with spiramycin, Group (III) infected treated with ginger and Group (IV) Infected treated with spiramycin plus ginger. All mice were scarified 60 days after infection. Parasitological measures through counting brain cysts and histopathological measures through using hematoxylin and eosin (H&E) were employed. Also, Sera of different groups were collected to detect levels of proinflammatory cytokines, interleukin 8 (IL-8) and interferon gamma (IFN-γ). Our results showed that ginger tablets are considered promising option for treatment chronic toxoplasmosis.

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