Does Leishmania infantum Use Degenerating Midgut Cells of The Vector as A Nutrient Source?

Document Type : Original Article

Authors

1 Research & Training Center on Vectors of Diseases, Ain Shams University, Cairo, Egypt

2 Imperial College, London, UK.

3 Faculty of Science, Ain Shams University, Cairo, Egypt

Abstract

Ultrastructural evidence from Phlebotomus
langeroni
experim-entally infected with Leishmania infantum
was found from day 4 postinfection to support the hypothesis that shed midgut
cells act as an important nutrient source for the parasite. Thirteen areas of
degenerating cells occurred in 12 sections of infected flies compared to none
in complementary controls 8 days post-infection. Parasites penetrated
degenerating cells in 7 of 30 flies sectioned (days 8-11 post-infection), and
were frequently found packed around shed cells in the gut lumen. No
melanisation was observed, suggesting that although higher cell turnover was
probably induced by parasites they did not destroy intact cells.

Keywords